A Simulation of High Latitude F-Layer Instabilities in the Presence of Magnetosphere-Ionosphere Coupling

A magnetic-field-line-integrated model of plasma interchange instabilities is developed for the high latitude ionosphere including magnetospheric coupling effects. We show that primary magnetosphere-ionosphere coupling effect is to incorporate the inertia of the magnetospheric plasma in the analysis. As a specific example, we present the first simulation of the E x B instability in the inertial regime, i.e., nu sub i omega where nu sub i is the ion-neutral collision frequency and omega is the wave frequency. We find that the inertial E x B instability develops in a fundamentally different manner than in the collisional case ni sub i omega. Our results show that striations produced in the inertial regime are spread and retarded by ion inertial effects, and result in more isotropic irregularities than those seen in the collisional case

Hybrid computer Monte-Carlo techniques

Hybrid analog-digital computer systems for Monte Carlo method application

Constructing Confidence Intervals For Flexible Budget Cost Estimates

A multiple-cost flexible budget can be constructed using either the Aggregate Cost Analysis Method or the Component Flexible Budget Method.  This paper derives and illustrates the use of a confidence interval formula for an annual cost estimate that is developed by summing 12 monthly flexible budget estimates

Methotrimeprazine versus haloperidol in palliative care patients with cancer-related nausea: a randomised, double-blind controlled trial.

OBJECTIVES:Methotrimeprazine is commonly used for the management of nausea but never tested formally against other drugs used in this setting. The aim was to demonstrate superior antiemetic efficacy. DESIGN:Double-blind, randomised, controlled trial of methotrimeprazine versus haloperidol. SETTING:11 palliative care sites in Australia. PARTICIPANTS:Participants were >18 years, had cancer, an average nausea score of ≥3/10 and able to tolerate oral medications. Ineligible patients had acute nausea related to treatment, nausea for which a specific antiemetic was indicated, were about to undergo a procedure or had received either of the study drugs or a change in glucocorticoid dose within the previous 48 hours. INTERVENTIONS:Based on previous studies, haloperidol was used as the control. Participants were randomised to encapsulated methotrimeprazine 6·25 mg or haloperidol 1·5 mg one time or two times per day and assessed every 24 hours for 72 hours. MAIN OUTCOME MEASURES:A ≥two-point reduction in nausea score at 72 hours from baseline. Secondary outcome measures were as follows: complete response at 72 hours (end nausea score less than 3), response at 24 and 48 hours, vomiting episodes, use of rescue antiemetics, harms and global impression of change. RESULTS:Response to treatment at 72 hours was 75% (44/59) in the haloperidol (H) arm and 63% (36/57) in the methotrimeprazine (M) arm with no difference between groups (intention-to-treat analysis). Complete response rates were 56% (H) and 51% (M). In the per protocol analysis, there was no difference in response rates: (85% (44/52) (H) and 74% (36/49) (M). Complete per protocol response rates were 64% (H) and 59% (M). Toxicity worse than baseline was minimal with a trend towards greater sedation in the methotrimeprazine arm. CONCLUSION:This study did not demonstrate any difference in response rate between methotrimeprazine and haloperidol in the control of nausea. TRIAL REGISTRATION NUMBER:ACTRN 12615000177550

Ramified rectilinear polygons: coordinatization by dendrons

Simple rectilinear polygons (i.e. rectilinear polygons without holes or cutpoints) can be regarded as finite rectangular cell complexes coordinatized by two finite dendrons. The intrinsic $l_1$-metric is thus inherited from the product of the two finite dendrons via an isometric embedding. The rectangular cell complexes that share this same embedding property are called ramified rectilinear polygons. The links of vertices in these cell complexes may be arbitrary bipartite graphs, in contrast to simple rectilinear polygons where the links of points are either 4-cycles or paths of length at most 3. Ramified rectilinear polygons are particular instances of rectangular complexes obtained from cube-free median graphs, or equivalently simply connected rectangular complexes with triangle-free links. The underlying graphs of finite ramified rectilinear polygons can be recognized among graphs in linear time by a Lexicographic Breadth-First-Search. Whereas the symmetry of a simple rectilinear polygon is very restricted (with automorphism group being a subgroup of the dihedral group $D_4$), ramified rectilinear polygons are universal: every finite group is the automorphism group of some ramified rectilinear polygon.Comment: 27 pages, 6 figure

Stability of a cubic fixed point in three dimensions. Critical exponents for generic N

The detailed analysis of the global structure of the renormalization-group (RG) flow diagram for a model with isotropic and cubic interactions is carried out in the framework of the massive field theory directly in three dimensions (3D) within an assumption of isotropic exchange. Perturbative expansions for RG functions are calculated for arbitrary $N$ up to the four-loop order and resummed by means of the generalized Pad$\acute{\rm e}$-Borel-Leroy technique. Coordinates and stability matrix eigenvalues for the cubic fixed point are found under the optimal value of the transformation parameter. Critical dimensionality of the model is proved to be equal to $N_c=2.89 \pm 0.02$ that agrees well with the estimate obtained on the basis of the five-loop \ve-expansion [H. Kleinert and V. Schulte-Frohlinde, Phys. Lett. B342, 284 (1995)] resummed by the above method. As a consequence, the cubic fixed point should be stable in 3D for $N\ge3$, and the critical exponents controlling phase transitions in three-dimensional magnets should belong to the cubic universality class. The critical behavior of the random Ising model being the nontrivial particular case of the cubic model when N=0 is also investigated. For all physical quantities of interest the most accurate numerical estimates with their error bounds are obtained. The results achieved in the work are discussed along with the predictions given by other theoretical approaches and experimental data.Comment: 33 pages, LaTeX, 7 PostScript figures. Final version corrected and added with an Appendix on the six-loop stud

Geo-environmental mapping using physiographic analysis: constraints on the evaluation of land instability and groundwater pollution hazards in the Metropolitan District of Campinas, Brazil

Geo-environmental terrain assessments and territorial zoning are useful tools for the formulation and implementation of environmental management instruments (including policy-making, planning, and enforcement of statutory regulations). They usually involve a set of procedures and techniques for delimitation, characterisation and classification of terrain units. However, terrain assessments and zoning exercises are often costly and time-consuming, particularly when encompassing large areas, which in many cases prevent local agencies in developing countries from properly benefiting from such assessments. In the present paper, a low-cost technique based on the analysis of texture of satellite imagery was used for delimitation of terrain units. The delimited units were further analysed in two test areas situated in Southeast Brazil to provide estimates of land instability and the vulnerability of groundwater to pollution hazards. The implementation incorporated procedures for inferring the influences and potential implications of tectonic fractures and other discontinuities on ground behaviour and local groundwater flow. Terrain attributes such as degree of fracturing, bedrock lithology and weathered materials were explored as indicators of ground properties. The paper also discusses constraints on- and limitations of- the approaches taken

Automated Analysis of Cryptococcal Macrophage Parasitism Using GFP-Tagged Cryptococci

The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening infections of the central nervous system. One of the major characteristics of cryptococcal disease is the ability of the pathogen to parasitise upon phagocytic immune effector cells, a phenomenon that correlates strongly with virulence in rodent models of infection. Despite the importance of phagocyte/Cryptococcus interactions to disease progression, current methods for assaying virulence in the acrophage system are both time consuming and low throughput. Here, we introduce the first stable and fully characterised GFP–expressing derivatives of two widely used cryptococcal strains: C. neoformans serotype A type strain H99 and C. gattii serotype B type strain R265. Both strains show unaltered responses to environmental and host stress conditions and no deficiency in virulence in the macrophage model system. In addition, we report the development of a method to effectively and rapidly investigate macrophage parasitism by flow cytometry, a technique that preserves the accuracy of current approaches but offers a four-fold improvement in speed